New Alzheimers Research
Medascape report a possible paradigm shift: Excess TNF-Alpha Emerges as a Key Therapeutic Target inAlzheimer's Disease..
You will need to register, it is free, pretty technical but this research seems to offer the possibility of new treatments and better understanding of Alzheimers
There is now substantial, and accumulating, basic science, genetic, and
clinical evidence that excess tumor necrosis factor (TNF) is centrally involved
in the pathogenesis of Alzheimer's disease.[1-26] New TNF data from the
renowned Framingham Study is the most recent robust scientific evidence supporting
a key role of excess TNF in Alzheimer's.[4] By negatively influencing
synaptic regulation and amyloid, glutamate, NMDA, and inflammatory pathways, excess
TNF, along with amyloid/tau, may constitute the "perfect storm" which attacks
the brain and results in Alzheimer's progression.[1-26] The new recognition
of the potential association of traumatic brain injury and Alzheimer's in
professional football players, the increasing attention deservedly being given
to the public health threat posed by Alzheimer's, and the increasing health
burden posed by the growing ranks of our young veterans afflicted by traumatic
brain injury underscores their unmet medical need. What is not yet widely
recognized is that these disorders are united by the common involvement of
excess TNF in their pathogenesis.[1-28]
Labels: Alzheimer's Disease new treatment
posted by Jen @ 8:09 AM
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